She played in Vaudeville until joining KFRC in 1926, where she was a regular on the "Blue Monday Jamboree" and "Happy Go Lucky Hour." That was followed by two decades with KPO and NBC, where she regularly appeared on Signal Oil's "Carefree Carnival" with Meredith Willson and Tommy Harris, fellow KFRC transplants. She also wrote that program's theme song.
Her own program, "Stars in the Making" on KPO, featured rising San Francisco music talent. Edna Fischer moved to television in the early 1950s, when she became Music Director of KPIX-TV (Channel 5).In 2006, she was elected to the Bay Area Radio Hall of Fame as a member of the first class to be inducted.